L-2-Hydroxyglutaric acid NLT 98%
SKU : MC517044
CAS Number : 13095-48-2
Molecular Formula : C5H8O5 | Molecular Weight : 148.11
Synonyms : (S)-2-Hydroxyglutaric acid
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | L-2-Hydroxyglutaric acid |
|---|---|
| CAS Number | 13095-48-2 |
| Molecular Formula | C5H8O5 |
| Molecular Weight | 148.11 |
| Synonyms | (S)-2-Hydroxyglutaric acid |
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2]. In Vitro: L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1].
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