Efaproxiral NLT 98%
Product Number : MC517195
CAS Number : 131179-95-8
Molecular Formula : C20H23NO4 | Molecular Weight : 341.40
Synonyms : RSR13
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
| MolCore specializes in manufacturing high-purity CAS No.131179-95-8, Efaproxiral with the molecular formula C20H23NO4 and molecular weight 341.40 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems. | |
* The above information is for reference only.
| Chemical Name | Efaproxiral |
|---|---|
| CAS Number | 131179-95-8 |
| MDL Number | MFCD00899086 |
| Molecular Formula | C20H23NO4 |
| Molecular Weight | 341.40 |
| Synonyms | RSR13 |
Efaproxiral is a haemoglobin (Hb) synthetic allosteric modifier, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy [1]. IC50 & Target: haemoglobin (Hb)[1] In Vitro: Efaproxiral binds to only one pair of symmetry-related sites in the Hb central water cavity[2].
Efaproxiral readily crosses the red cell membrane in the presence of serum albumin solutions[2].
Efaproxiral is not inhibited from entering erythrocytes in the presence of an anion-channel blocking agent (DIDS)[2].
In Vivo: Efaproxiral (150 mg/kg, i.p.) increase tumor oxygenation，and increase the tumor growth inhibition of radiotherapy over 5 days of treatment[3].
Efaproxiral reduces hemoglobin-oxygen binding affinity, which facilitates oxygen release from hemoglobin into surrounding tissues and potentially increases the pO(2) of the tumors[4]
© Copyright 2015-2025 Hangzhou MolCore BioPharmatech Co.,Ltd. All rights reserved.