SKU : MC517336
CAS Number : 131359-24-5
Molecular Formula : C17H14O3 | Molecular Weight : 266.29
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | 2-HBA |
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CAS Number | 131359-24-5 |
MDL Number | MFCD01790784 |
Molecular Formula | C17H14O3 |
Molecular Weight | 266.29 |
2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10. IC50 & Target: NQO1, caspase-3, caspase-10[1] In Vitro: When L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10[1].
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