SKU : MC517664
CAS Number : 1320288-17-2
Molecular Formula : C36H59N7O2 | Molecular Weight : 621.90
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | UNC0646 |
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CAS Number | 1320288-17-2 |
MDL Number | MFCD22378486 |
Molecular Formula | C36H59N7O2 |
Molecular Weight | 621.90 |
UNC0646 is a potent and selective histone methyltransferase G9a inhibitor with an IC50 of 6 nM. UNC0646 is also a potent GLP inhibitor (IC50 <15 nM) and highly selective for G9a/GLP over SETD7, SUV39H2, SETD8 and PRMT3. UNC0646 reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 26 nM[1]. In Vitro: UNC0646 (Compound 6) has high cellular potency and excellent separation of functional potency versus cell toxicity in a variety of cell lines. UNC0646 is highly potent in reducing H3K9me2 levels and has low cell toxicity. UNC0646 reduces H3K9me2 levels with ICW IC50 values of 26 nM, 10 nM, 12 nM, 14 nM, 68 nM, 86 nM and 10 nM in MDA-MB-231, MCF7, PC3, 22RV1, HCT116 wt, HCT 116 p53-/- and IMR90 cell lines, respectively[1].
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