Org-12962 NLT 98%

Org-12962 is a potent, selective and orally active 5-HT_2C receptor agonist with a pEC₅₀ value of 7.01. Org-12962 also exhibits high effacy for the 5-HT_2A and 5-HT_2B receptor with pEC₅₀s of 6.38 and 6.28, respectively^[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety^[2]. In Vivo: Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) significantly increases the postinjection frequency thresholds for self-interruption (F_3.71=11.40). Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%)^[1].