Angiotensin III, human, mouse NLT 98%
Product Number : MC519706
CAS Number : 13602-53-4
Molecular Formula : C46H66N12O9 | Molecular Weight : 931.09
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | Angiotensin III, human, mouse |
|---|---|
| CAS Number | 13602-53-4 |
| MDL Number | MFCD00167500 |
| Molecular Formula | C46H66N12O9 |
| Molecular Weight | 931.09 |
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively. IC50 & Target: IC50: 0.648 nM (AT2R), 21.1 nM (AT1R)[1] In Vitro: Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively[1]. In Vivo: Angiotensin III (7, 14 and 28 nmol/kg/min) increases urine sodium excretion (UNaV), fractional excretion of sodium (FENa), and fractional excretion of lithium (FELi) in SD rat[2]. In RAS (renin-angiotensin system), Angiotensin III increases sympathetic nerve activity and vasopressin release and decreases the baroreflex leading to higher blood pressure in rats[3].
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