SKU : MC520120
CAS Number : 136831-48-6
Molecular Formula : C16H14N2O2 | Molecular Weight : 266.29
Synonyms : Tyrphostin RG13022;
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | RG13022 |
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CAS Number | 136831-48-6 |
MDL Number | MFCD00236444 |
Molecular Formula | C16H14N2O2 |
Molecular Weight | 266.29 |
Synonyms | Tyrphostin RG13022; |
RG13022 is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor with an IC50 of 4 μM. IC50 & Target: IC50: 4 μM (EGF receptor autophosphorylation)[1] In Vitro: RG13022 suppresses EGF-stimulated cancer cell proliferation. In a cell-free reaction RG13022 inhibits the autophosphorylation reaction of the EGF receptor in immunoprecipitates with an IC50 of 4 μM. RG13022 inhibits colony formation and DNA synthesis by HER 14 cells, which were stimulated by 50 ng/mL EGF, in a dose-dependent manner. The IC50s are 1 and 3 μM for HER 14 colony formation and DNA synthesis, respectively[1]. RG-13022 inhibits not only EGF-induced growth but also growth stimulated by insulin, insulin-like growth factor I, insulin-like growth factor II, or transforming growth factor alpha. RG-13022 also totally blocks estrogen-stimulated phosphorylation of the EGF receptor, as well as estrogen-induced cell proliferation, suggesting that functioning TK pathways are required for estrogen action[2]. In Vivo: RG13022 suppresses tumor growth in nude mice. RG13022 also increases the life span of these tumor-bearing nude mice[1].
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