SKU : MC520912
CAS Number : 1383478-94-1
Molecular Formula : C27H31N3O3S2 | Molecular Weight : 509.68
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | CYM 9484 |
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CAS Number | 1383478-94-1 |
MDL Number | MFCD22683854 |
Molecular Formula | C27H31N3O3S2 |
Molecular Weight | 509.68 |
CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM[1]. In Vitro: SF-11 is a selective, brain-penetrant NPY Y2 receptor antagonist with an IC50 value of 190 nM. Systematically explore the SAR of the hit molecule SF-11 that leads to the identification of selective and highly potent small molecule NPY Y2 receptor antagonist CYM 9484 (Compound 16). CYM 9484 is 10-fold more potent than the hit molecule SF-11. CYM 9484 is prepared by the coupling of α,α-diphenylpiperidino-4-methanol with a variety of aryl isothiocyanates[1].
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