SKU : MC521234
CAS Number : 139110-80-8
Molecular Formula : C12H20N4O7 | Molecular Weight : 332.31
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Zanamivir |
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CAS Number | 139110-80-8 |
MDL Number | MFCD00866966 |
Molecular Formula | C12H20N4O7 |
Molecular Weight | 332.31 |
Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively. IC50 & Target: IC50: 0.95 nM (Influenza A); 2.7 nM (Influenza B)[1] In Vitro: Zanamivir interacts with a group of amino acids in the active site of neuraminidase, which are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which prevents the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions[2]. In Vivo: Zanamivir has a poor bioavailability in oral administration, with only 4–17% of the agent. Oral delivery of zanamivir has been a problem due to its strong hydrophilic nature that limits its transport across the intestinal epithelium. Permeation enhancers such as sodium cholate, hydroxypropyl β-cyclodextrin could be used with zanamivir to enhance the intestinal permeability[3].
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