ZM241385 NLT 98%
SKU : MC521286
CAS Number : 139180-30-6
Molecular Formula : C16H15N7O2 | Molecular Weight : 337.34
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
* The above information is for reference only.
* If the product has intellectual property rights, a license granted is must or contact us.
| Chemical Name | ZM241385 |
|---|---|
| CAS Number | 139180-30-6 |
| MDL Number | MFCD00908394 |
| Molecular Formula | C16H15N7O2 |
| Molecular Weight | 337.34 |
ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM[1][2][3]. IC50 & Target: Ki: 1.4 nM (A2AR)[2] In Vitro: ZM241385 (1 μM; 24 hours; PC12 cells) treatment reverses the phenomenon that A2AR agonist CGS21680 significantly upregulates A2AR mRNA levels[1].
ZM241385 (1 μM; 48 hours; PC12 cells) treatment reverses the phenomenon that A2AR agonist CGS21680 significantly increases A2AR protein levels[1]. In Vivo: ZM241385 (0.2 μg/mouse, 0.4 μg/mouse; intraperitoneal injection; every day; for 11 weeks; female C57BL/6 WT mice) treatment decreases tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC[4].
Related Products
© Copyright 2015-2024 Hangzhou MolCore BioPharmatech Co.,Ltd. All rights reserved.