SKU : MC521548
CAS Number : 139667-74-6
Molecular Formula : C15H24Cl2NO4P | Molecular Weight : 384.24
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | CGP52432 |
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CAS Number | 139667-74-6 |
MDL Number | MFCD09878290 |
Molecular Formula | C15H24Cl2NO4P |
Molecular Weight | 384.24 |
CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM. IC50 & Target: IC50: 85 nM (GABAB receptor)[1] In Vitro: CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively[1]. In Vivo: CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze[2]. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats[3].
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