SKU : MC522157
CAS Number : 14142-64-4
Molecular Formula : C18H24ClN3O5 | Molecular Weight : 397.85
Synonyms : Desethylhydroxychloroquine (oxalate)
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Cletoquine (oxalate) |
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CAS Number | 14142-64-4 |
MDL Number | MFCD18252381 |
Molecular Formula | C18H24ClN3O5 |
Molecular Weight | 397.85 |
Synonyms | Desethylhydroxychloroquine (oxalate) |
Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment[1][2]. IC50 & Target: Chikungunya virus (CHIKV)[2] In Vivo: Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5)[3].
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