SKU : MC523210
CAS Number : 142741-24-0
Molecular Formula : C44H50N4O10 | Molecular Weight : 794.89
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Conophylline |
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CAS Number | 142741-24-0 |
MDL Number | MFCD00940239 |
Molecular Formula | C44H50N4O10 |
Molecular Weight | 794.89 |
Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis[1][2]. In Vitro: Conophylline (100 ng/ml; 48 hours) reproduces differentiationinducing activity but not apoptosis-inducing activity of activin[1].
Conophylline (100 ng/ml; 72 hours) exhibits the differentiation-inducing activity in AR42J cells and converts these cells to endocrine cells[1].
Conophylline increases the expression of neurogenin-3 by activating p38 mitogen-activated protein kinase to induce differentiation of AR42J cells[1].
Conophylline reduces the expression of α-SMA and collagen-1 in rat HSC and Lx-2 cells[2].
Conophylline inhibits DNA synthesis induced by serum[2].
Conophylline also promots activation of caspase-3 and induces apoptosis in Lx-2 Cells[2].
In Vivo: Conophylline (0.9 mg/kg; p.o.; daily; for 12 weeks) attenuates formation of the liver fibrosis induced by TAA in vivo[2].
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