SKU : MC523387
CAS Number : 143-67-9
Molecular Formula : C46H60N4O13S | Molecular Weight : 909.05
Synonyms : Vincaleukoblastine sulfate salt
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Vinblastine (sulfate) |
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CAS Number | 143-67-9 |
MDL Number | MFCD08706468 |
Molecular Formula | C46H60N4O13S |
Molecular Weight | 909.05 |
Synonyms | Vincaleukoblastine sulfate salt |
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM. IC50 & Target: IC50: 8.9 μM(nAChR)[1] In Vitro: Vinblastine does not depolymerize spindle microtubules, yet it powerfully blocks mitosis (for example, IC50 0.8 nM in HeLa cells) and cells die by apoptosis[2]. In NB4 cells, vinblastine produces alteration of p53 and DNA fragmentation. Vinblastine treatment has an antiproliferative effect via the induction of apoptosis producing Bax/Bcl-2 imbalance. Vinblastine treatment suppresses NFκB expression and depresses NFκB-DNA binding activity while maintaining JNK activation that subsequently results in apoptotic response through caspase-dependent pathway[3]. Vinblastine is found to trigger apoptosis as evidenced by the loss of mitochondrial membrane potential, the release of both cytochrome c and apoptosis inducing factor, activation of caspase-9 and 3, and cleavage of Poly (ADP-ribose)-Polymerase[4]. In Vivo: Vinblastine is a widely used anticancer drug with undesired side effects. Its conjugation with carrier molecules could be an efficient strategy to reduce these side effects[5].
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