SKU : MC523565
CAS Number : 143360-00-3
Molecular Formula : C13H19NO | Molecular Weight : 205.30
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | SMIP004 |
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CAS Number | 143360-00-3 |
MDL Number | MFCD00277686 |
Molecular Formula | C13H19NO |
Molecular Weight | 205.30 |
SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells[1][2]. IC50 & Target: SKP2 E3 ligase[1] In Vitro: SMIP004 decreases the levels of positive cell cycle regulators, upregulates cyclin-dependent kinase inhibitors, and results in G1 arrest, inhibition of colony formation in soft agar, and cell death[2]. In Vivo: SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in SCID mice[2].
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