SKU : MC526174
CAS Number : 151227-08-6
Molecular Formula : C20H19ClN2O3S | Molecular Weight : 402.89
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | AP521 |
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CAS Number | 151227-08-6 |
MDL Number | MFCD00932423 |
Molecular Formula | C20H19ClN2O3S |
Molecular Weight | 402.89 |
AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM. IC50 & Target: IC50: 94 nM (5-HT1A (human))[1] In Vitro: AP521 is an agonist of human 5-HT1A receptor with IC50s of 135, 94, 254, 5530, 418, 422 and 198 nM for 5-HT1A (rat), 5-HT1A (human), 5-HT1B (rat), 5-HT1B (human), 5-HT1D (human), 5-HT5a (human) and 5-HT7 (rat), respectively. AP521 also decreases the forskolin-induced cAMP accumulation from 10 nM to 10 μM[1]. In Vivo: AP521 significantly increases the number of shock acceptances [F(5,105)=4.46, P<0.01] at doses between 0.5 to 10 mg/kg. Oral administration of AP521 at 3 and 10 mg/kg significantly decreases freezing time [F(3,60)=2.89, P<0.05]. AP521 significantly increases the time spent on the open arms by approximately 2-fold as compare to the vehicle treated group [F(3, 36)=4.21, P<0.05 for AP521]. The anxiolytic-like effect of AP521 appears to be dose-related. AP521 significantly increases the extracellular 5-HT level of the medial prefrontal cortex (mPFC) at 10 mg/kg from 0.5 to 1 h after administration. AP521 at 3 mg/kg tends to increase the extracellular 5-HT level, however, this increase is not significant[1].
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