151533-34-5

(Rac)-Acolbifene NLT 98%

Name: (Rac)-Acolbifene
Brand: Molcore
SKU: MC526248
Rating: 98 (39 reviews)

Product Number : MC526248

CAS Number : 151533-34-5

Molecular Formula : C29H31NO4 | Molecular Weight : 457.56

Synonyms : EM-343;(Rac)-EM-652

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Product Details

Purity	NLT 98%
Storage	at 20ºC 2 years
MolCore specializes in manufacturing high-purity CAS No.151533-34-5, (Rac)-Acolbifene with the molecular formula C29H31NO4 and molecular weight 457.56 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems.

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Chemical Name	(Rac)-Acolbifene
CAS Number	151533-34-5
MDL Number	MFCD09837712
Molecular Formula	C29H31NO4
Molecular Weight	457.56
Synonyms	EM-343;(Rac)-EM-652

Introduction of 151533-34-5 :

(Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380^[1]. In Vitro: (Rac)-Acolbifene (EM-343; (Rac)-EM-652) shows a inhibitory effect in T-47D cells with an IC₅₀ value of 0.110 nM^[1].
In Vivo: (Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice)^[1].