SKU : MC527044
CAS Number : 154447-36-6
Molecular Formula : C19H18ClNO3 | Molecular Weight : 343.80
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | LY294002 |
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CAS Number | 154447-36-6 |
MDL Number | MFCD01530034 |
Molecular Formula | C19H18ClNO3 |
Molecular Weight | 343.80 |
LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively[1]. LY294002 also inhibits CK2 with an IC50 of 98 nM[2]. LY294002 is a competitive DNA-PK inhibitorr that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. LY294002 is an autophagy and apoptosis activator[3]. IC50 & Target: IC50: 0.5 μM (p110α), 0.57 μM (p110δ), 0.97 μM (p110β)[1]
; 98 nM (human CK2), 3.869 μM (human CK2α2)[2]; 1.4 μM (DNA-PK)[3] In Vitro: LY294002 (0-75 μM; 24 hours and 48 hours) remarkably decreases human nasopharyngeal carcinoma CNE-2Z cells in a dose-dependent fashion[4].
LY294002 (0-75 μM; 24 hours and 48 hours ) induces CNE-2Z cells apoptosis rate in dose-dependent[4].
LY294002 (10-75 μM) significantly decreases p-Akt (S473) expression levels and up-regulates caspase-9 activity in CNE-2Z cells. Total Akt protein level is not difference with different concentration[4]. In Vivo: LY294002 (10, 25, 50, 75 mg/kg; i.p.; twice weekly; for 4 weeks) significantly reduces mean NPC tumor burden in a dose-dependent manner. LY294002 (10, 25 mg/kg) is less effective in decreasing tumor burden[4].
LY294002 (1.2 mg/kg per day; i.p.; for 14 days) prevents Leptin (60 ug/kg)-induced adverse effects on spermatozoa in Sprague-Dawley rats[5].
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