SKU : MC528373
CAS Number : 16009-13-5
Molecular Formula : C34H42ClFeN4O4 | Molecular Weight : 662.02
Synonyms : Hemin chloride
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Hemin |
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CAS Number | 16009-13-5 |
MDL Number | MFCD00010726 |
Molecular Formula | C34H42ClFeN4O4 |
Molecular Weight | 662.02 |
Synonyms | Hemin chloride |
Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer. IC50 & Target: Heme oxygenase[1] In Vitro: Hemin and PGJ2, used as positive controls, strongly increase both expression and activity of HMOX after 4 and 12 h, respectively. Indeed, a significant effect is found of 30 μM Hemin on cell proliferation in all used cell lines after 48 h, which is dose-dependent. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, enhancement of anti-proliferative effects of statins is observed by Hemin, documented as decreased cell proliferation after 48 h of co-treatment[1]. In Vivo: Following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules. The HO-2 level in the kidney does not change following Hemin preconditioning[2].
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