SKU : MC528519
CAS Number : 160754-76-7
Molecular Formula : C16H18ClN3S2 | Molecular Weight : 351.92
Synonyms : CNS5161;CNS 5161
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | CNS-5161 |
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CAS Number | 160754-76-7 |
MDL Number | MFCD09833785 |
Molecular Formula | C16H18ClN3S2 |
Molecular Weight | 351.92 |
Synonyms | CNS5161;CNS 5161 |
CNS-5161 is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate. IC50 & Target: NMDA receptor/ion channel[1] In Vitro: CNS-5161 (CNS 5161) is a novel and selective noncompetitive antagonist of the NMDA subset of glutamate receptors in the mammalian brain. CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain[1]. In Vivo: In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (CNS 5161) protects against the necrotic effects of exogenous N-methyl-D-aspartate with an ED80 of 4 mg/kg by the intraperitoneal (i.p.) route. CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p., and has a neuroprotective effect following hypoxix/ischaemic brain injury in neonatal rats[1].
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