Z-Ile-Leu-aldehyde NLT 98%
Product Number : MC528781
CAS Number : 161710-10-7
Molecular Formula : C20H30N2O4 | Molecular Weight : 362.46
Synonyms : Z-IL-CHO;GSI-XII;γ-Secretase inhibitor XII
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
| MolCore specializes in manufacturing high-purity CAS No.161710-10-7, Z-Ile-Leu-aldehyde with the molecular formula C20H30N2O4 and molecular weight 362.46 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems. | |
* The above information is for reference only.
| Chemical Name | Z-Ile-Leu-aldehyde |
|---|---|
| CAS Number | 161710-10-7 |
| MDL Number | MFCD04974201 |
| Molecular Formula | C20H30N2O4 |
| Molecular Weight | 362.46 |
| Synonyms | Z-IL-CHO;GSI-XII;γ-Secretase inhibitor XII |
Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch[1][2]. In Vitro: Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays[1].
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity[2]. In Vivo: Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment[2].
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