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161710-10-7 | Z-Ile-Leu-aldehyde

Z-Ile-Leu-aldehyde NLT 98%

SKU : MC528781

CAS Number : 161710-10-7

Molecular Formula : C20H30N2O4 | Molecular Weight : 362.46

Synonyms : Z-IL-CHO;GSI-XII;γ-Secretase inhibitor XII

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Z-Ile-Leu-aldehyde
CAS Number 161710-10-7
MDL Number MFCD04974201
Molecular Formula C20H30N2O4
Molecular Weight 362.46
Synonyms Z-IL-CHO;GSI-XII;γ-Secretase inhibitor XII
Introduction of 161710-10-7 :

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch[1][2]. In Vitro: Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays[1].
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity[2]. In Vivo: Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment[2].

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