Benzamil (hydrochloride) NLT 98%
SKU : MC528796
CAS Number : 161804-20-2
Molecular Formula : C13H15Cl2N7O | Molecular Weight : 356.21
Synonyms : Benzylamiloride (hydrochloride)
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | Benzamil (hydrochloride) |
|---|---|
| CAS Number | 161804-20-2 |
| MDL Number | MFCD00069219 |
| Molecular Formula | C13H15Cl2N7O |
| Molecular Weight | 356.21 |
| Synonyms | Benzylamiloride (hydrochloride) |
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3]. In Vitro: Benzamil hydrochloride (Benzylamiloride hydrochloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+ channels[4]. In Vivo: Benzamil hydrochloride (Benzylamiloride hydrochloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats[5].
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