HQL-79 NLT 98%
SKU : MC529069
CAS Number : 162641-16-9
Molecular Formula : C22H27N5O | Molecular Weight : 377.48
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | HQL-79 |
|---|---|
| CAS Number | 162641-16-9 |
| MDL Number | MFCD00936179 |
| Molecular Formula | C22H27N5O |
| Molecular Weight | 377.48 |
HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1]. IC50 & Target: IC50: 6 μM (H-PGDS)[1]
Kd: 0.8 μM (H-PGDS)[1] In Vitro: HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH[1].
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