SKU : MC529473
CAS Number : 163521-08-2
Molecular Formula : C26H27N5O2 | Molecular Weight : 441.52
Synonyms : EMD 68843 (Hydrochloride);SB659746A (Hydrochloride)
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Vilazodone (Hydrochloride) |
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CAS Number | 163521-08-2 |
MDL Number | MFCD09838919 |
Molecular Formula | C26H27N5O2 |
Molecular Weight | 441.52 |
Synonyms | EMD 68843 (Hydrochloride);SB659746A (Hydrochloride) |
Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist. IC50 & Target: SER; 5-HT1A[1]. In Vivo: Administration of 5-HT1A receptor agonists produce a characteristic behavioral syndrome that includes changes in posture, hind limb reduction, head weaving, tremors, forepaw treading, and straub tail. In the rat ultrasonic vocalizations test, stress-induced vocalizations are inhibited by Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (55 mg/kg po) at 120 and 210 min post dose. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (20-40 mg/kg ip), administered acutely or prophylactically (1 week prior to behavioral testing), attenuated stress induces potentiated startle but has no effect on stress potentiated anxiety response in the elevated plus maze. Interestingly, a lower dose of 10 mg/kg of Vilazodone Hydrochloride (EMD 68843 Hydrochloride) has the opposite effect in the startle response, indicating a somewhat unexplained bidirectional effect, and all doses produce a potentiation of the startle-induced stress response possibly suggestive of an anxiogenic-like response[1]. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) also represents another option for the treatment of MDD[2].
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