SKU : MC530255
CAS Number : 166095-21-2
Molecular Formula : C22H22Cl2N4O2 | Molecular Weight : 445.34
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | BMS-191095 |
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CAS Number | 166095-21-2 |
MDL Number | MFCD00953840 |
Molecular Formula | C22H22Cl2N4O2 |
Molecular Weight | 445.34 |
BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels. Target: potassium channel in vitro: BMS-191095 induces mitochondrial-depolarization and vasodilation. BMS-191095 elicites a dose-dependent vasodilation in endothelium denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively. in vivo: In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.
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