SKU : MC530684
CAS Number : 168835-82-3
Molecular Formula : C25H30N2O2 | Molecular Weight : 390.52
Synonyms : AG 1498;Tyrphostin SU 1498
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | SU1498 |
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CAS Number | 168835-82-3 |
MDL Number | MFCD03453026 |
Molecular Formula | C25H30N2O2 |
Molecular Weight | 390.52 |
Synonyms | AG 1498;Tyrphostin SU 1498 |
SU1498 is a selective inhibitor of the VEGFR2; inhibits Flk-1 with an IC50 of value of 700 nM. IC50 & Target: IC50:700 nM (Flk-1)[1] In Vitro: SU1498 stimulates accumulation of phosphorylated ERKs in human umbilical vein endothelial cells and in human aortic endothelial cells in a manner that is dependent on the functioning of the upstream components of the MAPK pathway, B-Raf, and MEK kinases. The enhanced accumulation of phospho-ERKs is observed only in cells that have been stimulated with sphingosine 1-phosphate or protein growth factors; SU1498 by itself is ineffective[2]. SU1498 blocks signal transduction from VEGFR2 in MS1 VEGF cells.In the presence of SU1498, levels of Ets-1 are decreased, suggesting that VEGF-VEGFR-2 interactions contributed to baseline levels of Ets-1 expression, and interruption of this autocrine interaction with SU1498 led to decreased expression of Ets-1[3]. SU1498 treatment significantly impacts U87 cell proliferation and apoptosis. SU1498 induces a marked increase in lipids and a decrease in glycerophosphocholine. Accordingly, accumulation of lipid droplets is seen in the cytoplasm of SU1498-treated U87 cells[4].
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