Jaceosidin NLT 98%

Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression^[1]. Jaceosidin exhibits anti-cancer^[2], anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation^[3]. In Vitro: Jaceosidin (30, 50, 75 μM) induces apoptosis in human renal carcinoma Caki cells after treatment for 24 h, shows no obvious effect on normal cells^[1].
Jaceosidin (75 μM) reduces MMP levels and causes cytochrome c release into the cytoplasm through Bax activation^[1].
Jaceosidin-mediated apoptosis is involved in downregulation of Mcl-1, c-FLIP expression, which is via inhibition of NF-κB and/or Sp1 transcriptional activity^[1].
Jaceosidin shows cytostatic activity to HES and HESC cells with IC₅₀s of 52.68 and 55.10 μM, and is less cytotocxic on Hec1 A and KLE (IC₅₀, 70.54, 147.14 μM, respectively), after treatment for 48 h^[2]. In Vivo: Jaceosidin (10 and 20 mg/kg, p.o., once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice^[3].
Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice^[3].
Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats^[3].