SKU : MC534216
CAS Number : 18296-44-1
Molecular Formula : C22H30O8 | Molecular Weight : 422.47
Synonyms : Valtrate
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Valepotriate |
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CAS Number | 18296-44-1 |
MDL Number | MFCD00868024 |
Molecular Formula | C22H30O8 |
Molecular Weight | 422.47 |
Synonyms | Valtrate |
Valepotriate, isolated from Valeriana jatamansi Jones, has anti-epileptic and anti-cancer activities[1][2]. In Vivo: Valepotriate showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50 values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB[2].
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