187665-65-2

PNU-142633 NLT 98%

Name: PNU-142633
Brand: Molcore
SKU: MC535058
Rating: 96 (40 reviews)

Product Number : MC535058

CAS Number : 187665-65-2

Molecular Formula : C24H30N4O3 | Molecular Weight : 422.52

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Specifications
Product Details

Purity	NLT 98%
Storage	at 20ºC 2 years
MolCore specializes in manufacturing high-purity CAS No.187665-65-2, PNU-142633 with the molecular formula C24H30N4O3 and molecular weight 422.52 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems.

* The above information is for reference only.

Chemical Name	PNU-142633
CAS Number	187665-65-2
MDL Number	MFCD10687093
Molecular Formula	C24H30N4O3
Molecular Weight	422.52

Introduction of 187665-65-2 :

PNU-142633 is a high affinity, selective and orally active 5-HT_1D receptor agonist with K_is of 6 nM and > 18 000 nM for human 5-HT_1D receptor and human 5-HT_1B receptor, respectively. PNU-142633 has anti-migraine efficacy^[1]^[2]. In Vitro: The intrinsic activity of PNU-142633 at the human 5-HT1D receptor is determined to be 70% that of 5-HT in a cytosensor cell-based assay compared with 84% for that of Sumatriptan^[1]. In Vivo: PNU-142633 (0.03-1 mg/kg; intravenous injection; male Hartley guinea pigs) treatment blocks neurogenic plasma protein extravasation. And PNU-142633 fails to alter resistance in these vascular beds^[1].