SKU : MC535177
CAS Number : 188196-22-7
Molecular Formula : C30H34FN5O5 | Molecular Weight : 563.62
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Frakefamide |
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CAS Number | 188196-22-7 |
MDL Number | MFCD09838485 |
Molecular Formula | C30H34FN5O5 |
Molecular Weight | 563.62 |
Frakefamide is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1][2]. In Vivo: Frakefamide (LEF576) yields a dose dependent increase in morphine appropriate responding to 50% at the highest dose tested (10 μmol/kg) after infusion durations of 2 min (Fig. 6, left panel), whereas after 15 min infusions a maximum of 25% morphine appropriate responding was occasioned at 17.5 μmol/kg[1][2].
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