SKU : MC535973
CAS Number : 192705-79-6
Molecular Formula : C20H24N6O3 | Molecular Weight : 396.44
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | PD-166866 |
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CAS Number | 192705-79-6 |
MDL Number | MFCD12922514 |
Molecular Formula | C20H24N6O3 |
Molecular Weight | 396.44 |
PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM. IC50 & Target: IC50: 52.4 nM (hFGFR1 tyrosine kinase)[1] In Vitro: PD 166866 inhibits human full-length FGFR-1 tyrosine kinase with an IC50 value of 52.4 nM and is characterized as an ATP competitive inhibitor of the FGFR-1. PD 166866 is a potent inhibitor of FGFR autophosphorylation in NIH 3T3 cells expressing endogenous FGFR-1 and in L6 cells overexpressing the human FGFR-1 tyrosine kinase. PD 166866 also inhibits bFGF-induced tyrosine phosphorylation of the 44- and 42-kDa (ERK 1/2) mitogen-activated protein kinase isoforms in L6 cells. Daily exposure of PD 166866 to L6 cells at concentrations from 1 to 100 nM results in a concentration-related inhibition of bFGF-stimulated cell growth for 8 consecutive days with an IC50 value of 24 nM[1].
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