SKU : MC536285
CAS Number : 193620-69-8
Molecular Formula : C23H19NO3 | Molecular Weight : 357.40
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | TAS-301 |
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CAS Number | 193620-69-8 |
MDL Number | MFCD05865245 |
Molecular Formula | C23H19NO3 |
Molecular Weight | 357.40 |
TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, and inhibits PKC activation induced by PDGF. IC50 & Target: PKC[1] In Vitro: TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca2+ influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively[1]. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM[2]. In Vivo: TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury[2].
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