MJ33-OH NLT 98%
SKU : MC537316
CAS Number : 199106-13-3
Molecular Formula : C22H43F3LiO6P | Molecular Weight : 498.48
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | MJ33-OH |
|---|---|
| CAS Number | 199106-13-3 |
| MDL Number | MFCD03787978 |
| Molecular Formula | C22H43F3LiO6P |
| Molecular Weight | 498.48 |
MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6[1]. In Vivo: MJ33 (0.5 μM/kg ; by tail vein, at 24 h before MCAO) significantly blocks the increase IL-1β, IL-17 and IL-23 in rats stimulated by Prdx6 siRNA treatment[2].
Compared with the Prdx6 siRNA group, combined exposure to Prdx6 siRNA and MJ33 significantly downregulates the mRNA and protein expression of NF-κB, iNOS and COX-2[2].
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