Methiothepin NLT 98%
Product Number : MC537930
CAS Number : 20229-30-5
Molecular Formula : C24H28N2O4S2 | Molecular Weight : 472.62
Synonyms : Methiothepine;Metitepine;Ro 8-6837
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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* The above information is for reference only.
| Chemical Name | Methiothepin |
|---|---|
| CAS Number | 20229-30-5 |
| MDL Number | MFCD00209930 |
| Molecular Formula | C24H28N2O4S2 |
| Molecular Weight | 472.62 |
| Synonyms | Methiothepine;Metitepine;Ro 8-6837 |
Methiothepin is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C). IC50 & Target: pKd: 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D)[1], 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), 8.99 (5-HT7)[3]
pKi: 8.50 (5-HT2A), 8.68 (5-HT2B), 8.35 (5-HT2C)[2] In Vitro: Methiothepin is a 5-HT receptor antagonist, with pKds of 7.10, 7.28, 7.56, and 6.99 for 5-HT1A, 5HT1B, 5HT1C, 5HT1D[1]. Methiothepin mesylate also shows pKds of 7.0, 7.8, 8.74, and 8.99 for 5-HT5A, 5-HT5B, 5-HT6, and 5-HT7, respectively[2]. Methiothepin exhibits high affinity at 5-HT2A, 5HT2B, and 5HT2C with pKis of 8.50, 8.68, and 8.35, respectively[3].
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