Fludarabine NLT 98%
Product Number : MC540936
CAS Number : 21679-14-1
Molecular Formula : C10H12FN5O4 | Molecular Weight : 285.23
Synonyms : F-ara-A;NSC 118218
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
| MolCore specializes in manufacturing high-purity CAS No.21679-14-1, Fludarabine with the molecular formula C10H12FN5O4 and molecular weight 285.23 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems. | |
* The above information is for reference only.
| Chemical Name | Fludarabine |
|---|---|
| CAS Number | 21679-14-1 |
| MDL Number | MFCD00132942 |
| Molecular Formula | C10H12FN5O4 |
| Molecular Weight | 285.23 |
| Synonyms | F-ara-A;NSC 118218 |
Introduction of 21679-14-1 :
Fludarabine (NSC 118218) is a DNA synthesis inhibitor, which also inhibits phosphorylation of STAT1. Fludarabine, a pro-drug, is converted metabolically by dephosphorylation to the antimetabolite, F-ara-A. In Vitro: Fludarabine (5 μM; 48 hours) induces a decrease in p27kip1 expression[4]. In Vivo: Fludarabine (0.8 mg/kg; i.p.; two cycles for 5 days every 2 weeks) in combination with Cyclophosphamide (400 mg/kg; i.p.; 2 weeks) decreases incidence of GVHD[5].
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