SKU : MC540936
CAS Number : 21679-14-1
Molecular Formula : C10H12FN5O4 | Molecular Weight : 285.23
Synonyms : F-ara-A;NSC 118218
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Fludarabine |
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CAS Number | 21679-14-1 |
MDL Number | MFCD00132942 |
Molecular Formula | C10H12FN5O4 |
Molecular Weight | 285.23 |
Synonyms | F-ara-A;NSC 118218 |
Fludarabine (NSC 118218) is a DNA synthesis inhibitor, which also inhibits phosphorylation of STAT1. Fludarabine, a pro-drug, is converted metabolically by dephosphorylation to the antimetabolite, F-ara-A. In Vitro: Fludarabine (5 μM; 48 hours) induces a decrease in p27kip1 expression[4]. In Vivo: Fludarabine (0.8 mg/kg; i.p.; two cycles for 5 days every 2 weeks) in combination with Cyclophosphamide (400 mg/kg; i.p.; 2 weeks) decreases incidence of GVHD[5].
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