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Uridine 5'-diphosphate (sodium salt)
Introduction of 21931-53-3 :
Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. IC50 & Target: EC50: 300 nM (P2Y6) pEC50: 6.52 (P2Y6) and 7.28 (P2Y14)In Vitro: Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression. Uridine 5'-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia. Uridine 5'-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h. UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level. Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia.