SKU : MC541418
CAS Number : 219680-11-2
Molecular Formula : C19H20FN5O4 | Molecular Weight : 401.39
Synonyms : DW-224a (Free base)
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Zabofloxacin |
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CAS Number | 219680-11-2 |
MDL Number | MFCD18633297 |
Molecular Formula | C19H20FN5O4 |
Molecular Weight | 401.39 |
Synonyms | DW-224a (Free base) |
Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP)[1]. IC50 & Target: IC50: bacterial; topoisomerases[1] In Vitro: Zabofloxacin shows a highly potent in vitro activity against clinical isolates of penicillin-sensitive S. pneumoniae (minimum inhibitory concentration, MIC90: 0.03 mg/L) and penicillin-resistant S. pneumoniae (MIC90: 0.03 mg/L). Against quinolone-resistant S. pneumoniae, zabofloxacin (MIC90: 1 mg/L) is more active than ciprofloxacin, sparfloxacin, and moxifloxacin[1].
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