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219680-11-2 | Zabofloxacin

Zabofloxacin NLT 98%

SKU : MC541418

CAS Number : 219680-11-2

Molecular Formula : C19H20FN5O4 | Molecular Weight : 401.39

Synonyms : DW-224a (Free base)

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Zabofloxacin
CAS Number 219680-11-2
MDL Number MFCD18633297
Molecular Formula C19H20FN5O4
Molecular Weight 401.39
Synonyms DW-224a (Free base)
Introduction of 219680-11-2 :

Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including Steptococcus aureusStreptococcus pyogenes and S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP)[1]. IC50 & Target: IC50: bacterial; topoisomerases[1] In Vitro: Zabofloxacin shows a highly potent in vitro activity against clinical isolates of penicillin-sensitive S. pneumoniae (minimum inhibitory concentration, MIC90: 0.03 mg/L) and penicillin-resistant S. pneumoniae (MIC90: 0.03 mg/L). Against quinolone-resistant S. pneumoniae, zabofloxacin (MIC90: 1 mg/L) is more active than ciprofloxacin, sparfloxacin, and moxifloxacin[1].

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