Valategrast NLT 98%
SKU : MC541729
CAS Number : 220847-86-9
Molecular Formula : C30H32Cl3N3O4 | Molecular Weight : 604.95
Synonyms : R-411 (free base)
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | Valategrast |
|---|---|
| CAS Number | 220847-86-9 |
| MDL Number | MFCD18782681 |
| Molecular Formula | C30H32Cl3N3O4 |
| Molecular Weight | 604.95 |
| Synonyms | R-411 (free base) |
Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2]. IC50 & Target: Integrin α4β1; Integrin α4β7[2] In Vitro: Valategrast contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS)[2].
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