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223104-29-8 | SEA0400

SEA0400 NLT 98%

SKU : MC542205

CAS Number : 223104-29-8

Molecular Formula : C21H19F2NO3 | Molecular Weight : 371.38

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name SEA0400
CAS Number 223104-29-8
MDL Number MFCD07772188
Molecular Formula C21H19F2NO3
Molecular Weight 371.38
Introduction of 223104-29-8 :

SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM. IC50 & Target: IC50: 5-33 nM (NCX) In Vitro: SEA0400 inhibits Na+-dependent 45Ca2+ uptake in cultured neurons, astrocytes, and microglia. IC50 values of SEA0400 are 33 nM (neurons), 5.0 nM (astrocytes), and 8.3 nM (microglia)[1]. SEA0400 prevents sodium nitroprusside (SNP) to increase ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca2+-dependent manner[2]. In Vivo: SEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats[1]. SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice[3].

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