SKU : MC542241
CAS Number : 223387-75-5
Molecular Formula : C12H9ClN2O4 | Molecular Weight : 280.66
Synonyms : IOX3;YM311
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | FG-2216 |
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CAS Number | 223387-75-5 |
MDL Number | MFCD23136998 |
Molecular Formula | C12H9ClN2O4 |
Molecular Weight | 280.66 |
Synonyms | IOX3;YM311 |
FG-2216 (IOX3; YM311) is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo. IC50 value: 3.9 uM [1] Target: PDH inhibitor FG-2216 was orally bioavailable and induced significant and reversible Epo induction in vivo (82- to 309-fold at 60 mg/kg). Chronic oral dosing in male rhesus macaques was well tolerated, significantly increased erythropoiesis, and prevented anemia induced by weekly phlebotomy. Furthermore, modest increases in HbF-containing red cells and reticulocytes were demonstrated by flow cytometry, though significant increases in HbF were not demonstrated by high-pressure liquid chromatography (HPLC) [2].
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