SKU : MC542443
CAS Number : 224785-91-5
Molecular Formula : C23H33ClN6O4S | Molecular Weight : 525.06
Quote RequestPurity | NLT 98% |
---|---|
Storage | at 20ºC 2 years |
* The above information is for reference only.
* If the product has intellectual property rights, a license granted is must or contact us.
Chemical Name | Vardenafil (hydrochloride) |
---|---|
CAS Number | 224785-91-5 |
MDL Number | MFCD07369690 |
Molecular Formula | C23H33ClN6O4S |
Molecular Weight | 525.06 |
Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction. Target: PDE5 Vardenafil specifically inhibited the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM (6.6 nM). In contrast, the IC50 of vardenafil for PDE1 was 180 nM; for PDE6, 11 nM; for PDE2, PDE3 and PDE4, more than 1000 nM. Relative to PDE5, the ratios of the IC50 for PDE1 were 257 (60), for PDE6 16 (7.4). Vardenafil significantly enhanced the SNP-induced relaxation of human trabecular smooth muscle at 3 nM (10 nM). Vardenafil also significantly potentiated both ACh-induced and transmural electrical stimulation-induced relaxation of trabecular smooth muscle [1]. Both vardenafil doses(10 mg or 20 mg) significantly enhanced the
© Copyright 2015-2024 Hangzhou MolCore BioPharmatech Co.,Ltd. All rights reserved.