SKU : MC543129
CAS Number : 232931-57-6
Molecular Formula : C31H32N4O6 | Molecular Weight : 556.61
Synonyms : NSC-694501
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | SJG-136 |
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CAS Number | 232931-57-6 |
MDL Number | MFCD19443671 |
Molecular Formula | C31H32N4O6 |
Molecular Weight | 556.61 |
Synonyms | NSC-694501 |
SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity. IC50 & Target: XL50: 45 nM (pBR322 DNA)[1] In Vitro: SJG-136 (dimer 5) is a DNA cross-linking agent, with an XL50 (concentration of agent required for 50% cross-linking of pBR322 DNA) of 45 nM for pBR322 DNA. SJG-136 is cytotoxic to ovarian cell lines, such as A2780 (IC50, 22.5 pM), A2780cisR (IC50, 24 pM), CH1 (IC50, 0.12 nM), CH1cisR (IC50, 0.6 nM), and SKOV-3 (IC50, 9.1 nM)[1]. SJG-136 (SG2000) also reduces the viability of a panel of canine cancer cells, with GI50 values ranging from 0.33 - >100 nM after a 1 h exposure, and <0.03 - 17.33 nM following continuous exposure[2]. In Vivo: SJG-136 shows more potent antitumor effect against CMeC-1 tumour at 0.30 mg/kg than 0.15 mg/kg either as a single dose or administered once a week for three weeks via dosed intravenously in mice. SJG-136-induced H2AX phosphorylation shows good correspondence, but less sensitivity, than measurement of foci[2].
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