SKU : MC543580
CAS Number : 24003-58-5
Molecular Formula : C16H27BrN2O | Molecular Weight : 343.30
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | QX-314 (bromide) |
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CAS Number | 24003-58-5 |
MDL Number | MFCD00083182 |
Molecular Formula | C16H27BrN2O |
Molecular Weight | 343.30 |
QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1]. IC50 & Target: sodium channel[1] In Vitro: QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro [1].
QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[1].
QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death [1].
QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 10% of control amplitude [3].
QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br- [3].
In Vivo: QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin[2].
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