SKU : MC544346
CAS Number : 251293-28-4
Molecular Formula : C64H88ClN13O18S2 | Molecular Weight : 1427.04
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Urotensin II (114-124), human |
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CAS Number | 251293-28-4 |
MDL Number | MFCD02684277 |
Molecular Formula | C64H88ClN13O18S2 |
Molecular Weight | 1427.04 |
Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14. IC50 & Target: GPR14[1] In Vitro: Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6)[1]. In Vivo: Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction[1].
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