SKU : MC544351
CAS Number : 251356-45-3
Molecular Formula : C24H22N2O3 | Molecular Weight : 386.44
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | SU16f |
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CAS Number | 251356-45-3 |
MDL Number | MFCD03452699 |
Molecular Formula | C24H22N2O3 |
Molecular Weight | 386.44 |
SU16f is a potent and selective PDGFRβ inhibitor with IC50s of 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively[1]. Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs (gastric cancer-derived mesenchymal stem cells) conditioned medium in gastric cancer cell proliferation and migration[2]. In Vitro: SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation[1].
SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM [1].
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