JPM-OEt NLT 98%
SKU : MC545169
CAS Number : 262381-84-0
Molecular Formula : C20H28N2O6 | Molecular Weight : 392.45
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | JPM-OEt |
|---|---|
| CAS Number | 262381-84-0 |
| MDL Number | MFCD16660940 |
| Molecular Formula | C20H28N2O6 |
| Molecular Weight | 392.45 |
JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity[1][2]. In Vivo: JPM-OEt (50 mg/kg; i.p.; daily for 30 days) reduces tumor cathepsin B activity significantly[1].
JPM-OEt (50 mg/kg; i.p.; twice daily for 4 weeks) leads to tumor regression in the RIP1-Tag2 (RT2) mouse model of pancreatic islet cell tumorigenesis[2].
JPM-OEt (50 mg/kg; i.p.; daily from 63 to 98 days) causes a significant delay in the increase of tumour burden during the first 2 weeks of treatment[3].
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