SKU : MC545722
CAS Number : 272105-42-7
Molecular Formula : C68H109N17O22S2 | Molecular Weight : 1580.82
Synonyms : P144
Quote RequestPurity | NLT 98% |
---|---|
Storage | at 20ºC 2 years |
* The above information is for reference only.
* If the product has intellectual property rights, a license granted is must or contact us.
Chemical Name | Disitertide |
---|---|
CAS Number | 272105-42-7 |
MDL Number | MFCD13195512 |
Molecular Formula | C68H109N17O22S2 |
Molecular Weight | 1580.82 |
Synonyms | P144 |
Disitertide (P144) is an inhibitor of TGF-β1. In Vitro: Disitertide (P144) prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter[1]. In Vivo: Treatment with Disitertide (P144) at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4[1].
© Copyright 2015-2024 Hangzhou MolCore BioPharmatech Co.,Ltd. All rights reserved.