(-)-DHMEQ NLT 98%
SKU : MC546440
CAS Number : 287194-40-5
Molecular Formula : C13H11NO5 | Molecular Weight : 261.23
Synonyms : Dehydroxymethylepoxyquinomicin
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | (-)-DHMEQ |
|---|---|
| CAS Number | 287194-40-5 |
| MDL Number | MFCD11100254 |
| Molecular Formula | C13H11NO5 |
| Molecular Weight | 261.23 |
| Synonyms | Dehydroxymethylepoxyquinomicin |
Introduction of 287194-40-5 :
(–)-DHMEQ is a potent NF-κB inhibitor. IC50 & Target: NF-κB[1] In Vitro: (–)-DHMEQ binds to cysteine 38 of RelA and cysteine 144 of RelB. (−)-DHMEQ at concentrations greater than 25 µM inhibits the LTβ-induced nuclear translocation of FLAG-RelB WT, whereas the inhibitory effect of (–)-DHMEQ on the nuclear translocation of FLAG-RelB (C144S) became weaker at the same concentrations[1].
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