Apratastat NLT 98%
SKU : MC546469
CAS Number : 287405-51-0
Molecular Formula : C17H22N2O6S2 | Molecular Weight : 414.50
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | Apratastat |
|---|---|
| CAS Number | 287405-51-0 |
| MDL Number | MFCD13152357 |
| Molecular Formula | C17H22N2O6S2 |
| Molecular Weight | 414.50 |
Introduction of 287405-51-0 :
Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) . Apratastat can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1].
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