SKU : MC546533
CAS Number : 2883-98-9
Molecular Formula : C12H16O3 | Molecular Weight : 208.25
Synonyms : α-Asarone;trans-Asarone
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | alpha-Asarone |
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CAS Number | 2883-98-9 |
Molecular Formula | C12H16O3 |
Molecular Weight | 208.25 |
Synonyms | α-Asarone;trans-Asarone |
alpha-Asarone (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice. In Vitro: The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that alpha-Asarone (α-Asarone) inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells[2]. In Vivo: The present results reveal that the acute treatment of alpha-Asarone (α-Asarone) elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (α-Asarone) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity[1].
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